The pandemic has therefore created an opportunity for strengthening and improving mental health using transformational approaches to build back better and fairer. To achieve this, however, far greater political will, financing, community mobilization, and social change are needed to ensure that mental health is afforded the priority it deserves, as part of rebuilding health and social systems, post COVID-19. To this end, the Pan American Health Organization has established a High-Level Commission on Mental Health and COVID-19 to guide the Organization and its Member States in improving mental health in the Americas.