Scientific Article
Parental Alcohol Problems May Alter Offspring’s Brain Functioning

Author
Enrico Amico, Mario Dzemidzic, Brandon G. Oberlin, Claire R. Carron, Jaroslaw Harezlak, Joaquín Goñi, David A. Kareken (E-mail: dkareken@iu.edu)
Citation
Enrico Amico, Mario Dzemidzic, Brandon G. Oberlin, Claire R. Carron, Jaroslaw Harezlak, Joaquín Goñi, David A. Kareken, The disengaging brain: Dynamic transitions from cognitive engagement and alcoholism risk, NeuroImage, Volume 209, 2020, 116515, ISSN 1053-8119, https://doi.org/10.1016/j.neuroimage.2020.116515.
  • Source
    NeuroImage
  • Release date
    01/04/2020

The disengaging brain: Dynamic transitions from cognitive engagement and alcoholism risk

Research article

Summary

Having a parent with an alcohol use disorder affects how the offspring’s brain transitions between active and resting states, according to new research.

The study reveals that the brain reconfigures itself between completing a mentally demanding task and resting. But the research shows that this reconfiguration does not take place in the brain of a person with a family history of an alcohol use disorder.

While the missing transition doesn’t seem to affect how well a person performs the mentally demanding task itself, it might be related to larger scale brain functions that give rise to behaviors associated with addiction. In particular, study subjects without this brain process demonstrated greater impatience in waiting for rewards, a behavior associated with addiction.

Abstract

Human functional brain connectivity is usually measured either at “rest” or during cognitive tasks, ignoring life’s moments of mental transition.

The researchers propose a different approach to understanding brain network transitions.

The researchers applied a novel independent component analysis of functional connectivity during motor inhibition (stop signal task) and during the continuous transition to an immediately ensuing rest. A functional network reconfiguration process emerged that:

  1. was most prominent in those without familial alcoholism risk,
  2. encompassed brain areas engaged by the task, yet
  3. appeared only transiently after task cessation.

The pattern was not present in a pre-task rest scan or in the remaining minutes of post-task rest.

Finally, this transient network reconfiguration related to a key behavioral trait of addiction risk: reward delay discounting.

These novel findings illustrate how dynamic brain functional reconfiguration during normally unstudied periods of cognitive transition might reflect addiction vulnerability, and potentially other forms of brain dysfunction.

Context

Alcoholism is highly prevalent and few affected receive treatment; after treatment, alcohol use relapse remains clinically significant. Understanding brain-related vulnerabilities is thus important to prevention and public health, especially given alcoholism’s comorbidity and joint risk with other mental illness.

Past research has shown that a family history of alcoholism affects a person’s brain anatomy and physiology, but most studies have looked at this effect only in separate active and quiet resting states rather than the transition between them.

A lot of what brains do is switch between different tasks and states. We suspected that this task switching might be somewhat lower in people with a family history of alcoholism,” says David Kareken, a professor of neurology at the Indiana University School of Medicine and director of the Indiana Alcohol Research Center, as per Futurity.

A family history of alcoholism stood out as the most statistically significant difference in this brain reconfiguration.

In the past, we’ve assumed that a person who doesn’t drink excessively is a ‘healthy’ control for a study. But this work shows that a person with just a family history of alcoholism may also have some subtle differences in how their brains operate,” says Joaquín Goñi, an assistant professor in the School of Industrial Engineering and the Weldon School of Biomedical Engineering at Purdue University, as per Futurity.

Source Website: Science Direct