Selection biases may lead to systematic overestimate of protective effects from ‘moderate’ alcohol consumption. Overall, most sources of selection bias favor low-volume alcohol users in relation to non-alcohol users.

Author

Timothy S. Naimi (E-mail: tim.naimi@bmc.org), Timothy Stockwell, Jinhui Zhao, Ziming Xuan, Frida Dangardt, Rich Saitz, Wenbin Liang, Tanya Chikritzhs

Citation

Naimi, T. S., Stockwell, T., Zhao, J., Xuan, Z., Dangardt, F., Saitz, R., Liang, W., and Chikritzhs, T. (2017) Selection biases in observational studies affect associations between ‘moderate’ alcohol consumption and mortality. Addiction, 112: 207– 214. doi: 10.1111/add.13451.


Source
Addiction
Release date
17/06/2016

Selection biases in observational studies affect associations between ‘moderate’ alcohol consumption and mortality

Addiction Debate

Abstract

Selection biases may lead to systematic overestimate of protective effects from ‘moderate’ alcohol consumption. Overall, most sources of selection bias favor low-volume alcohol users in relation to non-alcohol users.

Studies that attempt to address these types of bias generally find attenuated or non-significant relationships between low-volume alcohol consumption and cardiovascular disease, which is the major source of possible protective effects on mortality from low-volume consumption.

Furthermore, observed mortality effects among established low-volume consumers are of limited relevance to health-related decisions about whether to initiate consumption or to continue consuming alcohol purposefully into old age.

Short of randomized trials with mortality end-points, there are a number of approaches that can minimize selection bias involving low-volume alcohol consumption.


Source Website: Wiley Online Library