The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI.

The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden.

Author

GBD 2019 Cancer Risk Factors Collaborators

Citation

Tran, K., Lang, J., Compton, K., Xu, R., Acheson, A., Henrikson, H., Kocarnik, J., Penberthy, L., Aali, A., Abbas, Q., Abbasi, B., Abbasi-Kangevari, M., Abbasi-Kangevari, Z., Abbastabar, H., Abdelmasseh, M., Abd-Elsalam, S., Abdelwahab, A., Abdoli, G., Abdulkadir, H., Abedi, A., Abegaz, K., Abidi, H., Aboagye, R., Abolhassani, H., Absalan, A., Abtew, Y., Abubaker Ali, H., Abu-Gharbieh, E., Achappa, B., Acuna, J., Addison, D., Addo, I., Adegboye, O., Adesina, M., Adnan, M., Adnani, Q., Advani, S., Afrin, S., Afzal, M., Aggarwal, M., Ahinkorah, B., Ahmad, A., Ahmad, R., Ahmad, S., Ahmad, S., Ahmadi, S., Ahmed, H., Ahmed, L., Ahmed, M., Ahmed Rashid, T., Aiman, W., Ajami, M., Akalu, G., Akbarzadeh-Khiavi, M., Aklilu, A., Akonde, M., Akunna, C., Al Hamad, H., Alahdab, F., Alanezi, F., Alanzi, T., Alessy, S., Algammal, A., Al-Hanawi, M., Alhassan, R., Ali, B., Ali, L., Ali, S., Alimohamadi, Y., Alipour, V., Aljunid, S., Alkhayyat, M., Al-Maweri, S., Almustanyir, S., Alonso, N., Alqalyoobi, S., Al-Raddadi, R., Al-Rifai, R., Al-Sabah, S., Al-Tammemi, A., Altawalah, H., Alvis-Guzman, N., Amare, F., Ameyaw, E., Aminian Dehkordi, J., Amirzade-Iranaq, M., Amu, H., Amusa, G., Ancuceanu, R., Anderson, J., Animut, Y., Anoushiravani, A., Anoushirvani, A., Ansari-Moghaddam, A., Ansha, M., Antony, B., Antwi, M., Anwar, S., Anwer, R., Anyasodor, A., Arabloo, J., Arab-Zozani, M., Aremu, O., Argaw, A., Ariffin, H., Aripov, T., Arshad, M., Artaman, A., Arulappan, J., Aruleba, R., Aryannejad, A., Asaad, M., Asemahagn, M., Asemi, Z., Asghari-Jafarabadi, M., Ashraf, T., Assadi, R., Athar, M., Athari, S., Atout, M., Attia, S., Aujayeb, A., Ausloos, M., Avila-Burgos, L., Awedew, A., Awoke, M., Awoke, T., Ayala Quintanilla, B., Ayana, T., Ayen, S., Azadi, D., Azadnajafabad, S., Azami-Aghdash, S., Azanaw, M., Azangou-Khyavy, M., Azari Jafari, A., Azizi, H., Azzam, A., Babajani, A., Badar, M., Badiye, A., Baghcheghi, N., Bagheri, N., Bagherieh, S., Bahadory, S., Baig, A., Baker, J., Bakhtiari, A., Bakshi, R., Banach, M., Banerjee, I., Bardhan, M., Barone-Adesi, F., Barra, F., Barrow, A., Bashir, N., Bashiri, A., Basu, S., Batiha, A., Begum, A., Bekele, A., Belay, A., Belete, M., Belgaumi, U., Bell, A., Belo, L., Benzian, H., Berhie, A., Bermudez, A., Bernabe, E., Bhagavathula, A., Bhala, N., Bhandari, B., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bhojaraja, V., Bhuyan, S., Bibi, S., Bilchut, A., Bintoro, B., Biondi, A., Birega, M., Birhan, H., Bjørge, T., Blyuss, O., Bodicha, B., Bolla, S., Boloor, A., Bosetti, C., Braithwaite, D., Brauer, M., Brenner, H., Briko, A., Briko, N., Buchanan, C., Bulamu, N., Bustamante-Teixeira, M., Butt, M., Butt, N., Butt, Z., Caetano dos Santos, F., Cámera, L., Cao, C., Cao, Y., Carreras, G., Carvalho, M., Cembranel, F., Cerin, E., Chakraborty, P., Charalampous, P., Chattu, V., Chimed-Ochir, O., Chirinos-Caceres, J., Cho, D., Cho, W., Christopher, D., Chu, D., Chukwu, I., Cohen, A., Conde, J., Cortés, S., Costa, V., Cruz-Martins, N., Culbreth, G., Dadras, O., Dagnaw, F., Dahlawi, S., Dai, X., Dandona, L., Dandona, R., Daneshpajouhnejad, P., Danielewicz, A., Dao, A., Darvishi Cheshmeh Soltani, R., Darwesh, A., Das, S., Davitoiu, D., Davtalab Esmaeili, E., De la Hoz, F., Debela, S., Dehghan, A., Demisse, B., Demisse, F., Denova-Gutiérrez, E., Derakhshani, A., Derbew Molla, M., Dereje, D., Deribe, K., Desai, R., Desalegn, M., Dessalegn, F., Dessalegni, S., Dessie, G., Desta, A., Dewan, S., Dharmaratne, S., Dhimal, M., Dianatinasab, M., Diao, N., Diaz, D., Digesa, L., Dixit, S., Doaei, S., Doan, L., Doku, P., Dongarwar, D., dos Santos, W., Driscoll, T., Dsouza, H., Durojaiye, O., Edalati, S., Eghbalian, F., Ehsani-Chimeh, E., Eini, E., Ekholuenetale, M., Ekundayo, T., Ekwueme, D., El Tantawi, M., Elbahnasawy, M., Elbarazi, I., Elghazaly, H., Elhadi, M., El-Huneidi, W., Emamian, M., Engelbert Bain, L., Enyew, D., Erkhembayar, R., Eshetu, T., Eshrati, B., Eskandarieh, S., Espinosa-Montero, J., Etaee, F., Etemadimanesh, A., Eyayu, T., Ezeonwumelu, I., Ezzikouri, S., Fagbamigbe, A., Fahimi, S., Fakhradiyev, I., Faraon, E., Fares, J., Farmany, A., Farooque, U., Farrokhpour, H., Fasanmi, A., Fatehizadeh, A., Fatima, W., Fattahi, H., Fekadu, G., Feleke, B., Ferrari, A., Ferrero, S., Ferro Desideri, L., Filip, I., Fischer, F., Foroumadi, R., Foroutan, M., Fukumoto, T., Gaal, P., Gad, M., Gadanya, M., Gaipov, A., Galehdar, N., Gallus, S., Garg, T., Gaspar Fonseca, M., Gebremariam, Y., Gebremeskel, T., Gebremichael, M., Geda, Y., Gela, Y., Gemeda, B., Getachew, M., Getachew, M., Ghaffari, K., Ghafourifard, M., Ghamari, S., Ghasemi Nour, M., Ghassemi, F., Ghimire, A., Ghith, N., Gholamalizadeh, M., Gholizadeh Navashenaq, J., Ghozy, S., Gilani, S., Gill, P., Ginindza, T., Gizaw, A., Glasbey, J., Godos, J., Goel, A., Golechha, M., Goleij, P., Golinelli, D., Golitaleb, M., Gorini, G., Goulart, B., Grosso, G., Guadie, H., Gubari, M., Gudayu, T., Guerra, M., Gunawardane, D., Gupta, B., Gupta, S., Gupta, V., Gupta, V., Gurara, M., Guta, A., Habibzadeh, P., Haddadi Avval, A., Hafezi-Nejad, N., Hajj Ali, A., Haj-Mirzaian, A., Halboub, E., Halimi, A., Halwani, R., Hamadeh, R., Hameed, S., Hamidi, S., Hanif, A., Hariri, S., Harlianto, N., Haro, J., Hartono, R., Hasaballah, A., Hasan, S., Hasani, H., Hashemi, S., Hassan, A., Hassanipour, S., Hayat, K., Heidari, G., Heidari, M., Heidarymeybodi, Z., Herrera-Serna, B., Herteliu, C., Hezam, K., Hiraike, Y., Hlongwa, M., Holla, R., Holm, M., Horita, N., Hoseini, M., Hossain, M., Hossain, M., Hosseini, M., Hosseinzadeh, A., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Huang, J., Hugo, F., Humayun, A., Hussain, S., Hussein, N., Hwang, B., Ibitoye, S., Iftikhar, P., Ikuta, K., Ilesanmi, O., Ilic, I., Ilic, M., Immurana, M., Innos, K., Iranpour, P., Irham, L., Islam, M., Islam, R., Islami, F., Ismail, N., Isola, G., Iwagami, M., J, L., Jaiswal, A., Jakovljevic, M., Jalili, M., Jalilian, S., Jamshidi, E., Jang, S., Jani, C., Javaheri, T., Jayarajah, U., Jayaram, S., Jazayeri, S., Jebai, R., Jemal, B., Jeong, W., Jha, R., Jindal, H., John-Akinola, Y., Jonas, J., Joo, T., Joseph, N., Joukar, F., Jozwiak, J., Jürisson, M., Kabir, A., Kacimi, S., Kadashetti, V., Kahe, F., Kakodkar, P., Kalankesh, L., Kalankesh, L., Kalhor, R., Kamal, V., Kamangar, F., Kamath, A., Kanchan, T., Kandaswamy, E., Kandel, H., Kang, H., Kanno, G., Kapoor, N., Kar, S., Karanth, S., Karaye, I., Karch, A., Karimi, A., Kassa, B., Katoto, P., Kauppila, J., Kaur, H., Kebede, A., Keikavoosi-Arani, L., Kejela, G., Kemp Bohan, P., Keramati, M., Keykhaei, M., Khajuria, H., Khan, A., Khan, A., Khan, E., Khan, G., Khan, M., Khan, M., Khanali, J., Khatab, K., Khatatbeh, M., Khatib, M., Khayamzadeh, M., Khayat Kashani, H., Khazeei Tabari, M., Khezeli, M., Khodadost, M., Kim, M., Kim, Y., Kisa, A., Kisa, S., Klugar, M., Klugarová, J., Kolahi, A., Kolkhir, P., Kompani, F., Koul, P., Koulmane Laxminarayana, S., Koyanagi, A., Krishan, K., Krishnamoorthy, Y., Kucuk Bicer, B., Kugbey, N., Kulimbet, M., Kumar, A., Kumar, G., Kumar, N., Kurmi, O., Kuttikkattu, A., La Vecchia, C., Lahiri, A., Lal, D., Lám, J., Lan, Q., Landires, I., Larijani, B., Lasrado, S., Lau, J., Lauriola, P., Ledda, C., Lee, S., Lee, S., Lee, W., Lee, Y., Lee, Y., Legesse, S., Leigh, J., Leong, E., Li, M., Lim, S., Liu, G., Liu, J., Lo, C., Lohiya, A., Lopukhov, P., Lorenzovici, L., Lotfi, M., Loureiro, J., Lunevicius, R., Madadizadeh, F., Mafi, A., Magdeldin, S., Mahjoub, S., Mahmoodpoor, A., Mahmoudi, M., Mahmoudimanesh, M., Mahumud, R., Majeed, A., Majidpoor, J., Makki, A., Makris, K., Malakan Rad, E., Malekpour, M., Malekzadeh, R., Malik, A., Mallhi, T., Mallya, S., Mamun, M., Manda, A., Mansour-Ghanaei, F., Mansouri, B., Mansournia, M., Mantovani, L., Martini, S., Martorell, M., Masoudi, S., Masoumi, S., Matei, C., Mathews, E., Mathur, M., Mathur, V., McKee, M., Meena, J., Mehmood, K., Mehrabi Nasab, E., Mehrotra, R., Melese, A., Mendoza, W., Menezes, R., Mengesha, S., Mensah, L., Mentis, A., Mera-Mamián, A., Meretoja, T., Merid, M., Mersha, A., Meselu, B., Meshkat, M., Mestrovic, T., Miao Jonasson, J., Miazgowski, T., Michalek, I., Mijena, G., Miller, T., Mir, S., Mirinezhad, S., Mirmoeeni, S., Mirza-Aghazadeh-Attari, M., Mirzaei, H., Mirzaei, H., Misganaw, A., Misra, S., Mohammad, K., Mohammadi, E., Mohammadi, M., Mohammadian-Hafshejani, A., Mohammadpourhodki, R., Mohammed, A., Mohammed, S., Mohan, S., Mohseni, M., Moka, N., Mokdad, A., Molassiotis, A., Molokhia, M., Momenzadeh, K., Momtazmanesh, S., Monasta, L., Mons, U., Montasir, A., Montazeri, F., Montero, A., Moosavi, M., Moradi, A., Moradi, Y., Moradi Sarabi, M., Moraga, P., Morawska, L., Morrison, S., Morze, J., Mosapour, A., Mostafavi, E., Mousavi, S., Mousavi Isfahani, H., Mousavi Khaneghah, A., Mpundu-Kaambwa, C., Mubarik, S., Mulita, F., Munblit, D., Munro, S., Murillo-Zamora, E., Musa, J., Nabhan, A., Nagarajan, A., Nagaraju, S., Nagel, G., Naghipour, M., Naimzada, M., Nair, T., Naqvi, A., Narasimha Swamy, S., Narayana, A., Nassereldine, H., Natto, Z., Nayak, B., Ndejjo, R., Nduaguba, S., Negash, W., Nejadghaderi, S., Nejati, K., Neupane Kandel, S., Nguyen, H., Niazi, R., Noor, N., Noori, M., Noroozi, N., Nouraei, H., Nowroozi, A., Nuñez-Samudio, V., Nzoputam, C., Nzoputam, O., Oancea, B., Odukoya, O., Oghenetega, O., Ogunsakin, R., Oguntade, A., Oh, I., Okati-Aliabad, H., Okekunle, A., Olagunju, A., Olagunju, T., Olakunde, B., Olufadewa, I., Omer, E., Omonisi, A., Ong, S., Onwujekwe, O., Orru, H., Otstavnov, S., Oulhaj, A., Oumer, B., Owopetu, O., Oyinloye, B., P A, M., Padron-Monedero, A., Padubidri, J., Pakbin, B., Pakshir, K., Pakzad, R., Palicz, T., Pana, A., Pandey, A., Pandey, A., Pant, S., Pardhan, S., Park, E., Park, E., Park, S., Patel, J., Pati, S., Paudel, R., Paudel, U., Paun, M., Pazoki Toroudi, H., Peng, M., Pereira, J., Pereira, R., Perna, S., Perumalsamy, N., Pestell, R., Pezzani, R., Piccinelli, C., Pillay, J., Piracha, Z., Pischon, T., Postma, M., Pourabhari Langroudi, A., Pourshams, A., Pourtaheri, N., Prashant, A., Qadir, M., Quazi Syed, Z., Rabiee, M., Rabiee, N., Radfar, A., Radhakrishnan, R., Radhakrishnan, V., Raeisi, M., Rafiee, A., Rafiei, A., Raheem, N., Rahim, F., Rahman, M., Rahman, M., Rahman, M., Rahmani, A., Rahmani, S., Rahmanian, V., Rajai, N., Rajesh, A., Ram, P., Ramezanzadeh, K., Rana, J., Ranabhat, K., Ranasinghe, P., Rao, C., Rao, S., Rashedi, S., Rashidi, A., Rashidi, M., Rashidi, M., Ratan, Z., Rawaf, D., Rawaf, S., Rawal, L., Rawassizadeh, R., Razeghinia, M., Rehman, A., Rehman, I., Reitsma, M., Renzaho, A., Rezaei, M., Rezaei, N., Rezaei, N., Rezaei, N., Rezaei, S., Rezaeian, M., Rezapour, A., Riad, A., Rikhtegar, R., Rios-Blancas, M., Roberts, T., Rohloff, P., Romero-Rodríguez, E., Roshandel, G., Rwegerera, G., S, M., Saber-Ayad, M., Saberzadeh-Ardestani, B., Sabour, S., Saddik, B., Sadeghi, E., Saeb, M., Saeed, U., Safaei, M., Safary, A., Sahebazzamani, M., Sahebkar, A., Sahoo, H., Sajid, M., Salari, H., Salehi, S., Salem, M., Salimzadeh, H., Samodra, Y., Samy, A., Sanabria, J., Sankararaman, S., Sanmarchi, F., Santric-Milicevic, M., Saqib, M., Sarveazad, A., Sarvi, F., Sathian, B., Satpathy, M., Sayegh, N., Schneider, I., Schwarzinger, M., Šekerija, M., Senthilkumaran, S., Sepanlou, S., Seylani, A., Seyoum, K., Sha, F., Shafaat, O., Shah, P., Shahabi, S., Shahid, I., Shahrbaf, M., Shahsavari, H., Shaikh, M., Shaka, M., Shaker, E., Shannawaz, M., Sharew, M., Sharifi, A., Sharifi-Rad, J., Sharma, P., Shashamo, B., Sheikh, A., Sheikh, M., Sheikhbahaei, S., Sheikhi, R., Sheikhy, A., Shepherd, P., Shetty, A., Shetty, J., Shetty, R., Shibuya, K., Shirkoohi, R., Shirzad-Aski, H., Shivakumar, K., Shivalli, S., Shivarov, V., Shobeiri, P., Shokri Varniab, Z., Shorofi, S., Shrestha, S., Sibhat, M., Siddappa Malleshappa, S., Sidemo, N., Silva, D., Silva, L., Silva Julian, G., Silvestris, N., Simegn, W., Singh, A., Singh, A., Singh, G., Singh, H., Singh, J., Singh, J., Singh, P., Singh, S., Sinha, D., Sinke, A., Siraj, M., Sitas, F., Siwal, S., Skryabin, V., Skryabina, A., Socea, B., Soeberg, M., Sofi-Mahmudi, A., Solomon, Y., Soltani-Zangbar, M., Song, S., Song, Y., Sorensen, R., Soshnikov, S., Sotoudeh, H., Sowe, A., Sufiyan, M., Suk, R., Suleman, M., Suliankatchi Abdulkader, R., Sultana, S., Sur, D., Szócska, M., Tabaeian, S., Tabarés-Seisdedos, R., Tabatabaei, S., Tabuchi, T., Tadbiri, H., Taheri, E., Taheri, M., Taheri Soodejani, M., Takahashi, K., Talaat, I., Tampa, M., Tan, K., Tat, N., Tat, V., Tavakoli, A., Tavakoli, A., Tehrani-Banihashemi, A., Tekalegn, Y., Tesfay, F., Thapar, R., Thavamani, A., Thoguluva Chandrasekar, V., Thomas, N., Thomas, N., Ticoalu, J., Tiyuri, A., Tollosa, D., Topor-Madry, R., Touvier, M., Tovani-Palone, M., Traini, E., Tran, M., Tripathy, J., Ukke, G., Ullah, I., Ullah, S., Ullah, S., Unnikrishnan, B., Vacante, M., Vaezi, M., Valadan Tahbaz, S., Valdez, P., Vardavas, C., Varthya, S., Vaziri, S., Velazquez, D., Veroux, M., Villeneuve, P., Violante, F., Vladimirov, S., Vlassov, V., Vo, B., Vu, L., Wadood, A., Waheed, Y., Walde, M., Wamai, R., Wang, C., Wang, F., Wang, N., Wang, Y., Ward, P., Waris, A., Westerman, R., Wickramasinghe, N., Woldemariam, M., Woldu, B., Xiao, H., Xu, S., Xu, X., Yadav, L., Yahyazadeh Jabbari, S., Yang, L., Yazdanpanah, F., Yeshaw, Y., Yismaw, Y., Yonemoto, N., Younis, M., Yousefi, Z., Yousefian, F., Yu, C., Yu, Y., Yunusa, I., Zahir, M., Zaki, N., Zaman, B., Zangiabadian, M., Zare, F., Zare, I., Zareshahrabadi, Z., Zarrintan, A., Zastrozhin, M., Zeineddine, M., Zhang, D., Zhang, J., Zhang, Y., Zhang, Z., Zhou, L., Zodpey, S., Zoladl, M., Vos, T., Hay, S., Force, L. and Murray, C., 2022. The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 400(10352), pp.563-591.


Source
The Lancet
Release date
20/08/2022

The Global Burden of Cancer Attributable to Risk Factors, 2010–19: A Systematic Analysis for the Global Burden of Disease Study 2019

Abstract

Background

Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. This study analyzed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally.

Methods

The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented.

Findings

Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01–4.94) deaths and 105 million (95.0–116) DALYs for both sexes combined, representing 44.4% (41.3–48.4) of all cancer deaths and 42.0% (39.1–45.6) of all DALYs. There were 2.88 million (2.60–3.18) risk-attributable cancer deaths in males (50.6% [47.8–54.1] of all male cancer deaths) and 1.58 million (1.36–1.84) risk-attributable cancer deaths in females (36.3% [32·5–41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6–28.4) and DALYs by 16.8% (8.8–25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9–42.8] and 33.3% [25.8–42.0]).

Interpretation

The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden.


Source Website: The Lancet