Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling
- Alcohol is one of the most frequently used intoxicants in the United States. Binge alcohol use is a major contributor of emergency department visits.
- Binge alcohol use may adversely affect cardiovascular function.
- This study shows that acute alcohol intoxication is associated with elevated levels of cardiac endocannabinoid anandamide and profound cardiovascular dysfunction and blood redistribution lasting for several hours.
- The adverse cardiovascular effects of acute alcohol intoxication are attenuated by CB1-R antagonist or in CB1-R knockout mice.
- A single alcohol binge has profound effect on the cardiovascular system, which involves endocannabinoid-CB1-R signaling.
Excessive binge alcohol use may adversely affect cardiovascular function. In this study the researchers characterize the detailed hemodynamic effects of an acute alcohol binge in mice using multiple approaches and investigate the role of the endocannabinoid–cannabinoid 1 receptor (CB1-R) signaling in these effects.
Acute alcohol binge was associated with elevated levels of cardiac endocannabinoid anandamide and profound cardiovascular dysfunction lasting for several hours and redistribution of circulation. These changes were attenuated by CB1-R antagonist or in CB1-R knockout mice.
The results suggest that a single alcohol binge has profound effects on the cardiovascular system, which involve endocannabinoid–CB1-R signaling.